alternative complement pathway การใช้

• Accordingly, the alternative complement pathway is one element of innate immunity.
• Most cases are associated with the dysregulation of the alternative complement pathway.
• Recent studies indicated alterations in the complement system, including hyperactivation of the alternative complement pathway in patients with schizophrenia.
• Three biochemical pathways activate the complement system : the classical complement pathway, the alternative complement pathway, and the lectin pathway.
• The encoded protein is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents.
• Thus, the alternative complement pathway is able to distinguish self from non-self on the basis of the surface expression of complement regulatory proteins.
• The discovery of C3 like molecules in a diverse range of species suggests that the complement pathway in particular the alternative complement pathway is evolutionary ancient.
• The resistance of a genospecies of Lyme disease spirochetes to the bacteriolytic activities of the alternative complement pathway of various host species may determine its reservoir host association.
• Shiga-toxin directly activates the alternative complement pathway and also interferes with complement regulation by binding to complement factor H, an inhibitor of the complement cascade.
• In the alternative complement pathway, C3 is cleaved by C3bBb, another form of C3-convertase composed of activated forms of C3 ( C3b ) and factor B ( Bb ).
• He was the first to show that C3 nephritic factor is an autoantibody that activates the alternative complement pathway, a finding that suggested the potential of B cell or complement C5 depletion as adjunct therapies in certain forms of kidney inflammation.
• There are case reports of eculizumab being used to treat Shiga-toxin has been shown to trigger uncontrolled complement activity through direct activation of the alternative complement pathway as well as by binding to and inactivating the regulatory protein complement factor H.
• The presence of multiple Erp proteins was proposed to be important in allowing " B . burgdorferi " to evade killing by the alternative complement pathway of a broad range of potential animal hosts, as individual Erp proteins exhibited different binding patterns to the complement regulator factor H from different animals.
• Fa ( fHbp ) that is exhibited in " N . meningitidis " and some commensal species is the main inhibitor of the alternative complement pathway . fHbp protects meningococci from complement-mediated death in human serum experiments, but has also been shown to protect meningococci from antimicrobial peptides " in vitro ".